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Does USCIS issue a single RFE for all concerns in a petition or one RFE for each concern ?

Typically, USCIS will review an entire petition and, if deemed necessary, issue a single RFE that addresses all of their concerns. USCIS is not, however, limited in its ability to issue RFEs, and so they can issue any number of RFEs pertaining to any or all concerns they have regarding a particular petition.