No, either spouse may serve as the principal applicant; this will have no real bearing on the EB-5 application. If the spouses are from different nations, for instance, either spouse’s home nation can be used as the nation of chargeability. As for the source of funds, the personal assets of one spouse, the other, or both may be included in the investment—their assets are interchangeable. That said, when deciding which spouse will serve as the principal applicant, a couple should consult with an experienced EB-5 immigration attorney to ensure the I-526 Petition and source of funds documentation are as clean and clear as possible to avoid any unnecessary delays and/or requests for evidence (RFEs).